Back to Search Start Over

Donor-dependent variation of human umbilical cord blood mesenchymal stem cells in response to hypoxic preconditioning and amelioration of limb ischemia

Authors :
Insung Kang
Byung-Chul Lee
Soon Won Choi
Jin Young Lee
Jae-Jun Kim
Bo-Eun Kim
Da-Hyun Kim
Seung Eun Lee
Nari Shin
Yoojin Seo
Hyung-Sik Kim
Dong-Ik Kim
Kyung-Sun Kang
Source :
Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-15 (2018)
Publication Year :
2018
Publisher :
Nature Publishing Group, 2018.

Abstract

Stem cell therapy: Finding the best cells Stem cells from some donors have a stronger therapeutic effect than others, and can be identified by genetic markers. Adult or mesenchymal stem cells (MSCs), which can differentiate into many other cell types, show promise to treat many diseases. Kyung-Sun Kang at Seoul National University and co-workers investigated whether MSCs from some donors show better therapeutic efficacy than others. They tested MSCs from several donors in a mouse model simulating a stroke in a hindlimb, and measured regrowth of blood vessels. MSCs from one donor showed higher regenerative efficacy, triggering regrowth of many blood vessels and allowing the limb to be saved. Kang and co-workers used genetic analysis to identify genes that showed higher expression in these MSCs. This gene expression profile could be used to select MSCs with a higher regenerative capacity.

Subjects

Subjects :
Medicine
Biochemistry
QD415-436

Details

Language :
English
ISSN :
20926413
Volume :
50
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Experimental and Molecular Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.38f690bd11e408ca6d0b06c1480f45b
Document Type :
article
Full Text :
https://doi.org/10.1038/s12276-017-0014-9