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Bone marrow oxidative stress and specific antioxidant signatures in myelodysplastic syndromes

Authors :
Frederic Picou
Christine Vignon
Christelle Debeissat
Sébastien Lachot
Olivier Kosmider
Nathalie Gallay
Amelie Foucault
Marie-Hélène Estienne
Noémie Ravalet
Marie C. Bene
Jorge Domenech
Emmanuel Gyan
Michaela Fontenay
Olivier Herault
Source :
Blood Advances, Vol 3, Iss 24, Pp 4271-4279 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders with an inherent tendency for transformation in secondary acute myeloid leukemia. This study focused on the redox metabolism of bone marrow (BM) cells from 97 patients compared with 25 healthy controls. The level of reactive oxygen species (ROS) was quantified by flow cytometry in BM cell subsets as well as the expression level of 28 transcripts encoding for major enzymes involved in the antioxidant cellular response. Our results highlight increased ROS levels in BM nonlymphoid cells and especially in primitive CD34posCD38low progenitor cells. Moreover, we identified a specific antioxidant signature, dubbed “antioxidogram,” for the different MDS subgroups or secondary acute myeloblastic leukemia (sAML). Our results suggest that progression from MDS toward sAML could be characterized by 3 successive molecular steps: (1) overexpression of enzymes reducing proteic disulfide bonds (MDS with

Details

Language :
English
ISSN :
24739529
Volume :
3
Issue :
24
Database :
Directory of Open Access Journals
Journal :
Blood Advances
Publication Type :
Academic Journal
Accession number :
edsdoj.392527cb66544af0a6ede332d9be87d6
Document Type :
article
Full Text :
https://doi.org/10.1182/bloodadvances.2019000677