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Development, validation, and usage of metrics to evaluate the quality of clinical research hypotheses

Authors :
Xia Jing
Yuchun Zhou
James J. Cimino
Jay H. Shubrook
Vimla L. Patel
Sonsoles De Lacalle
Aneesa Weaver
Chang Liu
Source :
BMC Medical Research Methodology, Vol 25, Iss 1, Pp 1-10 (2025)
Publication Year :
2025
Publisher :
BMC, 2025.

Abstract

Abstract Objectives Metrics and instruments can provide guidance for clinical researchers to assess their potential research projects at an early stage before significant investment. Furthermore, metrics can also provide structured criteria for peer reviewers to assess others’ clinical research manuscripts or grant proposals. This study aimed to develop, test, validate, and use evaluation metrics and instruments to accurately, consistently, systematically, and conveniently assess the quality of scientific hypotheses for clinical research projects. Materials and methods Metrics development went through iterative stages, including literature review, metrics and instrument development, internal and external testing and validation, and continuous revisions in each stage based on feedback. Furthermore, two experiments were conducted to determine brief and comprehensive versions of the instrument. Results The brief version of the instrument contained three dimensions: validity, significance, and feasibility. The comprehensive version of metrics included novelty, clinical relevance, potential benefits and risks, ethicality, testability, clarity, interestingness, and the three dimensions of the brief version. Each evaluation dimension included 2 to 5 subitems to evaluate the specific aspects of each dimension. For example, validity included clinical validity and scientific validity. The brief and comprehensive versions of the instruments included 12 and 39 subitems, respectively. Each subitem used a 5-point Likert scale. Conclusion The validated brief and comprehensive versions of metrics can provide standardized, consistent, systematic, and generic measurements for clinical research hypotheses, allow clinical researchers to prioritize their research ideas systematically, objectively, and consistently, and can be used as a tool for quality assessment during the peer review process.

Details

Language :
English
ISSN :
14712288
Volume :
25
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Medical Research Methodology
Publication Type :
Academic Journal
Accession number :
edsdoj.3a5e52ad4a80477ba557631c66e3102d
Document Type :
article
Full Text :
https://doi.org/10.1186/s12874-025-02460-1