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Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

Authors :
Henning Jacobsen
Kerstin Walendy-Gnirß
Nilgün Tekin-Bubenheim
Nancy Mounogou Kouassi
Isabel Ben-Batalla
Nikolaus Berenbrok
Martin Wolff
Vinicius Pinho dos Reis
Martin Zickler
Lucas Scholl
Annette Gries
Hanna Jania
Andreas Kloetgen
Arne Düsedau
Gundula Pilnitz-Stolze
Aicha Jeridi
Ali Önder Yildirim
Helmut Fuchs
Valerie Gailus-Durner
Claudia Stoeger
Martin Hrabe de Angelis
Tatjana Manuylova
Karin Klingel
Fiona J. Culley
Jochen Behrends
Sonja Loges
Bianca Schneider
Susanne Krauss-Etschmann
Peter Openshaw
Gülsah Gabriel
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Influenza infection during pregnancy can affect health of offspring but it is not clear how this affects immune responses. Here the authors use a mouse model to show that influenza infection during pregnancy can increase susceptibility to secondary infection and alter immune cell function in offspring.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3a6daa33a83457bb051d8afd208dbb6
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25220-3