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Treatment and Systemic Sclerosis Interstitial Lung Disease Outcome: The Overweight Paradox

Authors :
Alexandra Nagy
Erik Palmer
Lorinc Polivka
Noemi Eszes
Krisztina Vincze
Eniko Barczi
Aniko Bohacs
Adam Domonkos Tarnoki
David Laszlo Tarnoki
György Nagy
Emese Kiss
Pal Maurovich-Horvat
Veronika Müller
Source :
Biomedicines, Vol 10, Iss 2, p 434 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

(1) Background: Systemic sclerosis (SSc) is frequently associated with interstitial lung diseases (ILDs). The progressive form of SSc-ILD often limits patient survival. The aim of our study is to evaluate the clinical characteristics and predictors of lung function changes in SSc-ILD patients treated in a real-world setting. (2) Methods: All SSc-ILD cases previously confirmed by rheumatologists and a multidisciplinary ILD team between January 2017 and June 2019 were included (n = 54). The detailed medical history, clinical parameters and HRCT were analyzed. The longitudinal follow-up for pulmonary symptoms, functional parameters and treatment were performed for at least 2 years in no treatment, immunosuppression and biological treatment subgroups. (3) Results: In SSc-ILD patients (age 58.7 ± 13.3 years, 87.0% women), the main symptoms included dyspnea, cough, crackles and the Raynaud’s phenomenon. The functional decline was most prominent in untreated patients, and a normal body mass index (BMI < 25 kg/m2) was associated with a significant risk of deterioration. The majority of patients improved or were stable during follow-up. The progressive fibrosing-ILD criteria were met by 15 patients, the highest proportion being in the untreated subgroup. (4) Conclusions: SSc-ILD patients who are overweight are at a lower risk of the functional decline and progressive phenotype especially affecting untreated patients. The close monitoring of lung involvement and a regular BMI measurement are advised and early treatment interventions are encouraged.

Details

Language :
English
ISSN :
22279059
Volume :
10
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.3a76629f637e4444b42359532ac3a382
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines10020434