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The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies
- Source :
- Frontiers in Neuroscience, Vol 12 (2018)
- Publication Year :
- 2018
- Publisher :
- Frontiers Media S.A., 2018.
-
Abstract
- Silent mating type information regulation 2 homolog 1 (Sirt1), a nicotine adenine dinucleotide (NAD+)-dependent enzyme, is well-known in playing a part in longevity. Ischemic stroke is a major neurological disorder and is a leading cause of death and adult disability worldwide. Recently, many studies have focused on the role of Sirt1 in ischemic stroke. Numerous studies consider Sirt1 as a protective factor and investigate the signaling pathways involved in the process under ischemic stress. However, the answer to whether upregulation of Sirt1 improves the outcome of stroke is still a controversy. In this review, we discuss the role and mechanisms of Sirt1 in the setting of ischemic stroke.
Details
- Language :
- English
- ISSN :
- 1662453X
- Volume :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3a93d381b0da44a09a7505907634a5a1
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fnins.2018.00833