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Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage
- Source :
- Jichu yixue yu linchuang, Vol 43, Iss 3, Pp 486-489 (2023)
- Publication Year :
- 2023
- Publisher :
- Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College., 2023.
-
Abstract
- Subarachnoid hemorrhage (SAH) leads to ferroptosis with clinical evidence like iron metabolism deregulation, increased lipid peroxitation(LPO) and the inhibition of glutathione/glutathione peroxides 4(GSH/GPX4). Ferroptosis mediated early brain injury (EBI) may occur in the 72-hour period following SAH (EBI-SAH) leads to the poor prognosis of SAH. Pharmacological targeting at ferroptosis mitigate EBI-SAH, provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis.
Details
- Language :
- Chinese
- ISSN :
- 10016325
- Volume :
- 43
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Jichu yixue yu linchuang
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3ba8b21ddd51496ead90013268e05655
- Document Type :
- article
- Full Text :
- https://doi.org/10.16352/j.issn.1001-6325.2023.03.486