Two Cu(II) coordination polymers: Photocatalytic Cr(VI) reduction and treatment activity on influenza A virus infection by inducing IFITM expression

Via H4L (5,5′-(1,3,6,8-tetraoxobenzo [lmn] [3], [8] phenanthroline-2–7-diyl) bis-1,3-benzenedicarboxylic acid), the rigid π-conjugated connector reacting with different N-donor auxiliary connectors and Cu(NO3)2·3H2O under the solvothermal conditions, two new coordination polymers (CPs) based on Cu ions as nodes {[Cu(H2L)(4,4′-bibp)(H2O)2]}n (1) and {[Cu(L)0.5(4,4′-bimb)(H2O)2]·3·.5H2O·2DMA}n (2) {4,4′-bimb = 4,4′-bis(imidazol-1-ylmethyl) bipheny and 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl, DMA = N,N- dimethylacetamide} were prepared and characterized. The photocatalytic reduction of Cr(VI) and dye degradation were performed with these two CPs. The results showed that under the ultraviolet irradiation, they revealed excellent photocatalytic reduction of Cr(VI) in thirty minutes, and the reduction efficiency was over 98%. According to results of the in vitro macrophage infectious model, in comparison with complex 2, complex 1 has stronger treatment activity on influenza A virus infection. Then, the ELISA test exhibited that complex could significantly regulated the releasing the INF-γ, but not complex 2. Next, the results of RT-PCR suggested that complex 1 is much better than complex 2 on reducing the relative expression of the interferon inducible transmembrane proteins (IFITM). Finally, the western blot further confirmed the induced ability of complex 1 on the IFITM in protein level.