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Altered Cerebral Blood Flow in Alzheimer's Disease With Depression

Authors :
Runzhi Li
Yanling Zhang
Zhizheng Zhuo
Yanli Wang
Ziyan Jia
Mengfan Sun
Yuan Zhang
Wenyi Li
Yunyun Duan
Zeshan Yao
Haoyi Weng
Juan Wei
Yaou Liu
Jun Xu
Source :
Frontiers in Psychiatry, Vol 12 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Background: Depression is common in Alzheimer's disease (AD) with an unclear neural mechanism. This study aimed to investigate the underlying cerebral perfusion associated with depression in AD and evaluate its clinical significance.Method: Twenty-one AD patients and 21 healthy controls (HCs) were enrolled in this study. The depressive symptom was defined according to the Hamilton Depression Rating Scale (HAMD). Nine patients were diagnosed as AD with depression symptoms (HAMD >7). Three-dimensional pseudocontinuous arterial spin labeling MR imaging was conducted to measure regional cerebral blood flow (CBF). Neuropsychological tests covered cognition and depressive scores. Between-group comparisons on clinical variables and regional CBFs, relationship between regional CBF and depressive score, and identification of AD patients with depression were performed using covariance analysis, linear regression, and receiver operating characteristic (ROC) analysis, respectively.Results: Compared with HCs, AD patients without depression exhibited lower gray matter CBF (p = 0.016); compared with AD patients without depression, AD patients with depression had higher CBF in the right supplementary motor area (39.23 vs. 47.91 ml/100 g/min, p = 0.017) and right supramarginal gyrus (35.54 vs. 43.85 ml/100 g/min, p = 0.034). CBF in the right supplementary motor area was correlated with depressive score (β = 0.46, p = 0.025). The combination of CBF in the right supplementary motor area and supramarginal gyrus and age could identify AD patients with depression from those without depression with a specificity of 100%, sensitivity of 66.67%, accuracy of 85.71%, and area under the curve of 0.87.Conclusions: Our findings suggested that hyperperfusion of the right supplementary motor area and right supramarginal gyrus were associated with depression syndrome in AD, which could provide a potential neuroimaging marker to evaluate the depression state in AD.

Details

Language :
English
ISSN :
16640640
Volume :
12
Database :
Directory of Open Access Journals
Journal :
Frontiers in Psychiatry
Publication Type :
Academic Journal
Accession number :
edsdoj.3c7f2e42e9f24fd08c2213258e59b169
Document Type :
article
Full Text :
https://doi.org/10.3389/fpsyt.2021.687739