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Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden

Authors :
Guanhua Zhu
Yu A. Guo
Danliang Ho
Polly Poon
Zhong Wee Poh
Pui Mun Wong
Anna Gan
Mei Mei Chang
Dimitrios Kleftogiannis
Yi Ting Lau
Brenda Tay
Wan Jun Lim
Clarinda Chua
Tira J. Tan
Si-Lin Koo
Dawn Q. Chong
Yoon Sim Yap
Iain Tan
Sarah Ng
Anders J. Skanderup
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3c974350bb8a41b0a12aa9c3b0c56857
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22463-y