Back to Search Start Over

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

Authors :
Daniel Fox
Anukriti Mathur
Yansong Xue
Yunqi Liu
Wei Hong Tan
Shouya Feng
Abhimanu Pandey
Chinh Ngo
Jenni A. Hayward
Ines I. Atmosukarto
Jason D. Price
Matthew D. Johnson
Nadja Jessberger
Avril A. B. Robertson
Gaetan Burgio
David C. Tscharke
Edward M. Fox
Denisse L. Leyton
Nadeem O. Kaakoush
Erwin Märtlbauer
Stephen H. Leppla
Si Ming Man
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3d1c668fd514f4c9ccf1972f0c941e9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-14534-3