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Expert Systems for Predicting the Bioavailability of Sun Filters in Cosmetic Products, Software vs. Expert Formulator: The Benzophenone-3 Case

Authors :
Anna Baldisserotto
Erika Baldini
Sara Ravarotto
Elena Cesa
Daniela De Lucia
Elisa Durini
Silvia Vertuani
Stefano Manfredini
Bozena B. Michniak-Kohn
Source :
Pharmaceutics, Vol 14, Iss 9, p 1815 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

There are only a limited number of molecules in a cosmetic formulation, which can passively cross the stratum corneum and be absorbed into the skin layers. However, some actives should never cross the skin in large concentrations due to their potential for side effects, for example, sunscreens. Artificial intelligence is gaining an increasing role as a predictive tool, and in this regard, we selected the Formulating for Efficacy® Software to forecast the changes in bioavailability of selected topical cosmetic compounds. Using the Franz diffusion cell methodology, various oils were selected as those with low release capability, and these were compared to those suggested by the software in Benzophenone-3-containing formulations. The software was able to predict the lipophilic phases, which, if utilized in the emulsion, were stable and sometimes even more pleasant in appearance and consistency than the reference emulsions prepared by the formulator. To date, however, Formulating for Efficacy® Software still has limitations as far as predicting the hydrophilic phase, as well as not being able to choose the emulsifier or the preservative system.

Details

Language :
English
ISSN :
19994923
Volume :
14
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.3e3e8d8e07f4f32bae3e187c89b7ce9
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics14091815