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IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- T cells help B cells to differentiate into antibody-producing plasma cells. Here the authors show that T cells produce interleukin-2 to activate ERK/ELK1 and suppress BACH2 expression by modulating the BACH2 super-enhancer, thereby altering BACH2 downstream transcription programs for plasma cell differentiation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3ec2df437fa44eea5f94d2e5946e484
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-01475-7