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A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells

Authors :
Haipeng Fu
Tingyu Wang
Xiaohui Kong
Kun Yan
Yang Yang
Jingyi Cao
Yafei Yuan
Nan Wang
Kehkooi Kee
Zhi John Lu
Qiaoran Xi
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Fu et al. identify the highly conserved, transmembrane micropeptide, NEMEP, as a direct target of Nodal signaling, essential for mesendoderm differentiation. NEMEP interacts with the glucose transporters GLUT1/GLUT3 and promotes glucose uptake.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3ec7c912d0c845bc86e050e581c46bdd
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31762-x