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Expression of activator protein-1 in papillary thyroid carcinoma and its clinical significance
- Source :
- World Journal of Surgical Oncology, Vol 17, Iss 1, Pp 1-5 (2019)
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Abstract Background The abnormal expression of activator protein-1(AP-1) has recently been investigated in a variety of tumors. While the relationship between AP-1 and thyroid cancer is poorly studied, our study was to evaluate the protein expression and clinical value of AP-1 in papillary thyroid carcinoma (PTC). Methods The expression of AP-1 was examined by immunohistochemistry on paraffin-embedded tissues obtained from PTC and correspondent paracancerous tissues of 82 patients. Results Compared with paracancerous tissues, AP-1 expression was significantly elevated in PTC tissues and the positive rate was 79.3% (65/82). Our study found a linear trend relationship between the expression of AP-1 and tumor size. However, the differences in AP-1 expression among gender, age, lymph node metastasis, number of lesions, location of the lesion, and extrathyroid invasion are not statistically significant. Conclusions The expression of AP-1 plays an important role in the proliferation process of PTC.
Details
- Language :
- English
- ISSN :
- 14777819
- Volume :
- 17
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- World Journal of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3ee8d50305fb47f193e1b6ece83aca22
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12957-019-1568-x