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Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab

Authors :
Gaik Tin Quah
Gillian Blanchard
Neil Miller
Paul Wilson
Ina Nordman
Source :
Cancer Reports, Vol 5, Iss 10, Pp n/a-n/a (2022)
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Abstract Background In malignancy, eosinophils have been shown to play an important role in the tumour micro‐environment. Increasingly, development of eosinophilia with immune checkpoint inhibitor (ICI) use is thought to be predictive of prognosis and development of immune‐related adverse events. However, there are many other causes for developing eosinophilia which can contribute to the difficulties in diagnosis and management. Case Here, we present a case of Strongyloides parasitic infection as an uncommon differential for eosinophilia in a patient with lung cancer receiving a PDL‐1 ICI, durvalumab, in Australia. Conclusion This case highlights the complexities exploring the multiple potential causes of eosinophilia and the subsequent management, to allow safe continuation of ICI.

Details

Language :
English
ISSN :
25738348
Volume :
5
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Cancer Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.3f76d5676bfc4c358730d5adfe2f3e2a
Document Type :
article
Full Text :
https://doi.org/10.1002/cnr2.1682