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Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions

Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions

Authors :
Jiayong Cui
Shengjun Chai
Rui Liu
Guoshuang Shen
Source :
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12214-12229 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Breast cancer represents one of the most prevalent malignant neoplasms affecting women, and its pathogenesis has garnered significant scholarly interest. Research indicates that the progression of breast cancer is intricately regulated by glucose metabolism. Under hypoxic conditions within the tumor microenvironment, breast cancer cells generate ATP and essential biosynthetic precursors for growth via the glycolytic pathway. Notably, phosphoglycerate kinase 1 (PGK1) is intimately associated with the regulation of hypoxia-inducible factors in breast cancer and plays a crucial role in modulating glycolytic processes. Further investigation into the role of PGK1 in breast cancer pathogenesis is anticipated to identify novel therapeutic targets and strategies. This review consolidates current research on the regulation of glucose metabolism and the function of PGK1 in breast cancer within hypoxic conditions. It aims to offer a significant theoretical foundation for elucidating the mechanisms underlying breast cancer progression and metastasis, thereby facilitating the development of innovative treatment approaches.

Details

Language :
English
ISSN :
14673045 and 14673037
Volume :
46
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Current Issues in Molecular Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.3fa6d5253d1a4d8cbe0a3fef443d6b64
Document Type :
article
Full Text :
https://doi.org/10.3390/cimb46110725