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Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions
Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions
- Source :
- Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12214-12229 (2024)
- Publication Year :
- 2024
- Publisher :
- MDPI AG, 2024.
-
Abstract
- Breast cancer represents one of the most prevalent malignant neoplasms affecting women, and its pathogenesis has garnered significant scholarly interest. Research indicates that the progression of breast cancer is intricately regulated by glucose metabolism. Under hypoxic conditions within the tumor microenvironment, breast cancer cells generate ATP and essential biosynthetic precursors for growth via the glycolytic pathway. Notably, phosphoglycerate kinase 1 (PGK1) is intimately associated with the regulation of hypoxia-inducible factors in breast cancer and plays a crucial role in modulating glycolytic processes. Further investigation into the role of PGK1 in breast cancer pathogenesis is anticipated to identify novel therapeutic targets and strategies. This review consolidates current research on the regulation of glucose metabolism and the function of PGK1 in breast cancer within hypoxic conditions. It aims to offer a significant theoretical foundation for elucidating the mechanisms underlying breast cancer progression and metastasis, thereby facilitating the development of innovative treatment approaches.
- Subjects :
- breast cancer
hypoxia
HIF-1α
glycolysis
PGK1
Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 14673045 and 14673037
- Volume :
- 46
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Current Issues in Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3fa6d5253d1a4d8cbe0a3fef443d6b64
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cimb46110725