Back to Search Start Over

Epileptogenic high-frequency oscillations present larger amplitude both in mesial temporal and neocortical regions

Authors :
Victor Karpychev
Alexandra Balatskaya
Nikita Utyashev
Nikita Pedyash
Andrey Zuev
Olga Dragoy
Tommaso Fedele
Source :
Frontiers in Human Neuroscience, Vol 16 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

High-frequency oscillations (HFO) are a promising biomarker for the identification of epileptogenic tissue. While HFO rates have been shown to predict seizure outcome, it is not yet clear whether their morphological features might improve this prediction. We validated HFO rates against seizure outcome and delineated the distribution of HFO morphological features. We collected stereo-EEG recordings from 20 patients (231 electrodes; 1,943 contacts). We computed HFO rates (the co-occurrence of ripples and fast ripples) through a validated automated detector during non-rapid eye movement sleep. Applying machine learning, we delineated HFO morphological features within and outside epileptogenic tissue across mesial temporal lobe (MTL) and Neocortex. HFO rates predicted seizure outcome with 85% accuracy, 79% specificity, 100% sensitivity, 100% negative predictive value, and 67% positive predictive value. The analysis of HFO features showed larger amplitude in the epileptogenic tissue, similar morphology for epileptogenic HFO in MTL and Neocortex, and larger amplitude for physiological HFO in MTL. We confirmed HFO rates as a reliable biomarker for epilepsy surgery and characterized the potential clinical relevance of HFO morphological features. Our results support the prospective use of HFO in epilepsy surgery and contribute to the anatomical mapping of HFO morphology.

Details

Language :
English
ISSN :
16625161
Volume :
16
Database :
Directory of Open Access Journals
Journal :
Frontiers in Human Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.3fb3bd96f81c4729af97fc5fe57c1fea
Document Type :
article
Full Text :
https://doi.org/10.3389/fnhum.2022.984306