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Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease
- Source :
- Gut Microbes, Vol 12, Iss 1 (2020)
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- Parkinson’s disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen Citrobacter rodentium resulted in the development of PD-like pathology in Pink1−/- mice compared to wild-type littermates. This addendum aims to expand this work by characterizing the gut microbiota during C. rodentium infection in our Pink1−/- PD model. We observed little disturbance to the fecal microbiota diversity both between infection timepoints and between Pink1−/- and wild-type control littermates. However, the level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1−/- mice and isobutyric acid increasing in wild-type mice.
Details
- Language :
- English
- ISSN :
- 19490976 and 19490984
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Gut Microbes
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3fb4f6846e754f969654c6ca079484cf
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/19490976.2020.1830694