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TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3fc4fb45806142b6abbf012e462c3364
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-04994-z