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Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies

Authors :
Ishrat Khan
R Harshithkumar
Ashwini More
Anupam Mukherjee
Source :
Pathogens, Vol 12, Iss 4, p 564 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

HPV, or Human Papilloma Virus, has been the primary causative agent of genital warts and cervical cancer worldwide. It is a sexually transmitted infection mainly affecting women of reproductive age group, also infecting men and high-risk group individuals globally, resulting in high mortality. In recent years, HPV has also been found to be the major culprit behind anogenital cancers in both gender and oropharyngeal and colorectal cancers. Few studies have reported the incidence of HPV in breast cancers as well. For a few decades, the burden of HPV-associated malignancies has been increasing at an alarming rate due to a lack of adequate awareness, famine vaccine coverage and hesitancy. The effectiveness of currently available vaccines has been limited to prophylactic efficacy and does not prevent malignancies associated with post-exposure persistent infection. This review focuses on the current burden of HPV-associated malignancies, their causes and strategies to combat the growing prevalence of the cancers. With the advent of new technologies associated with treatment pertaining to therapeutic interventions and employing effective vaccine coverage, the burden of this disease may be reduced in the population.

Details

Language :
English
ISSN :
20760817
Volume :
12
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
edsdoj.414bbefe927242699944c275df8c4c2f
Document Type :
article
Full Text :
https://doi.org/10.3390/pathogens12040564