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CT‐IGFBP‐4 as a novel prognostic biomarker in acute heart failure

Authors :
Alexey A. Konev
Alexey V. Kharitonov
Fedor N. Rozov
Evgeny P. Altshuler
Daria V. Serebryanaya
Johan Lassus
Veli‐Pekka Harjola
Alexey G. Katrukha
Alexander B. Postnikov
Source :
ESC Heart Failure, Vol 7, Iss 2, Pp 434-444 (2020)
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

Abstract Aims Insulin‐like growth factor binding protein‐4 (IGFBP‐4) fragments have been shown to predict the risk of major adverse cardiovascular events, including segment‐elevation myocardial infarction, in patients with acute coronary syndrome. We evaluated the prognostic value of the carboxy‐terminal fragment of IGFBP‐4 (CT‐IGFBP‐4) for all‐cause mortality in emergency room patients with acute heart failure (AHF). Methods and results CT‐IGFBP‐4, N‐terminal pro brain natriuretic peptide (NT‐proBNP), and C‐reactive protein (CRP) were measured at admission from the lithium‐heparin plasma of 156 patients with AHF. All‐cause mortality was recorded for 1 year. Receiver operator characteristic (ROC) curves, Kaplan–Meier, and Cox proportional hazard ratio analyses were performed to evaluate the prognostic value of the various clinical variables, CT‐IGFBP‐4, NT‐proBNP, CRP, and their combinations. During 1 year of follow‐up, 52 (33.3%) patients died. CT‐IGFBP‐4 only weakly correlated with NT‐proBNP (Pearson correlation coefficient r = 0.16, P = 0.044) and did not correlate with CRP (r = 0.08, P = 0.35), emphasizing the different nature of these biomarkers. The receiver operator characteristic area under the curve (ROC AUC) of CT‐IGFBP‐4 for the prediction of all‐cause mortality (0.727) was significantly higher than that of NT‐proBNP (0.680, P = 0.045) and CRP (0.669, P = 0.016). The combination of CT‐IGFBP‐4, NT‐proBNP, and CRP predicted mortality significantly better (ROC AUC = 0.788) than any of the biomarkers alone (P

Details

Language :
English
ISSN :
20555822
Volume :
7
Issue :
2
Database :
Directory of Open Access Journals
Journal :
ESC Heart Failure
Publication Type :
Academic Journal
Accession number :
edsdoj.41aef45ef974481f87b4f209ec85bdfb
Document Type :
article
Full Text :
https://doi.org/10.1002/ehf2.12590