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Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits

Authors :
Bingxin Zhao
Yue Shan
Yue Yang
Zhaolong Yu
Tengfei Li
Xifeng Wang
Tianyou Luo
Ziliang Zhu
Patrick Sullivan
Hongyu Zhao
Yun Li
Hongtu Zhu
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Brain structural traits are highly heritable and have been linked to disease. Here the authors have used gene expression data to perform a transcriptome-wide association study on 211 brain structural traits, discovering 273 associated genes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.41c53e39c6b4004b0b33daeee32b305
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23130-y