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Assessment of normalized cerebral blood flow and its connectivity with migraines without aura during interictal periods by arterial spin labeling

Authors :
Di Zhang
Xiaobin Huang
Cunnan Mao
Yuchen Chen
Zhengfei Miao
Chunmei Liu
Chenjie Xu
Xinying Wu
Xindao Yin
Source :
The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background Migraine constitutes a global health burden, and its pathophysiology is not well-understood; research evaluating cerebral perfusion and altered blood flow between brain areas using non-invasive imaging techniques, such as arterial spin labeling, have been scarce. This study aimed to assess cerebral blood flow (CBF) and its connectivity of migraine. Methods This study enrolled 40 patients with episodic migraine without aura (MwoA), as well as 42 healthy patients as control (HC). Two groups of normalized CBF and CBF connectivity were compared, and the relationship between CBF variation and clinical scale assessment was further evaluated. Results In comparison to HC subjects, MwoA patients exhibited higher CBF in the right middle frontal orbital gyrus (ORBmid.R) and the right middle frontal gyrus, while that in Vermis_6 declined. The increased CBF of ORBmid.R was positively correlated with both the Visual Light Sensitivity Questionnaire-8 (VLSQ-8) and the monthly attack frequency score. In MwoA, significantly decreased CBF connectivity was detected between ORBmid.R and the left superior frontal gyrus, the right putamen, the right caudate, as well as the right angular gyrus. In addition, increased CBF connectivity was observed between the left calcarine cortex and ORBmid.R. Conclusions Our results indicate that migraine patients exhibit abnormalities in regional CBF and feature CBF connection defects at the resting state. The affected areas involve information perception, information integration, and emotional, pain and visual processing. Our findings might provide important clues for the pathophysiology of migraine.

Details

Language :
English
ISSN :
11292369 and 11292377
Volume :
22
Issue :
1
Database :
Directory of Open Access Journals
Journal :
The Journal of Headache and Pain
Publication Type :
Academic Journal
Accession number :
edsdoj.420ef192bfda42d4b0d82b61f6b2a10f
Document Type :
article
Full Text :
https://doi.org/10.1186/s10194-021-01282-y