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Detection of early Alzheimer's disease in MCI patients by the combination of MMSE and an episodic memory test

Authors :
Berciano José
González-Perez Soraya
Sánchez-Juan Pascual
Mateo Ignacio
Vazquez-Higuera José
Rodríguez-Rodríguez Eloy
Pozueta Ana
Combarros Onofre
Source :
BMC Neurology, Vol 11, Iss 1, p 78 (2011)
Publication Year :
2011
Publisher :
BMC, 2011.

Abstract

Abstract Background Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally available. We aimed to investigate baseline clinical and neuropsychological variables that might predict progression from MCI to AD dementia. Methods All patients underwent a complete clinical and neuropsychological evaluation at baseline and every 6 months during a two-year follow-up period, with 54 out of 109 MCI patients progressing to dementia (50 of them progressed to AD dementia), and 55 remaining as stable MCI (S-MCI). Results A combination of MMSE and California Verbal Learning Test Long Delayed Total Recall (CVLT-LDTR) constituted the best predictive model: subjects scoring above 26/30 on MMSE and 4/16 on CVLT-LDTR had a negative predictive value of 93.93% at 2 years, whereas those subjects scoring below both of these cut-off scores had a positive predictive value of 80.95%. Conclusions Pr-AD might be distinguished from S-MCI at baseline using the combination of MMSE and CVLT-LDTR. These two neuropsychological predictors are relatively brief and may be readily completed in non-specialist clinical settings.

Details

Language :
English
ISSN :
14712377
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Neurology
Publication Type :
Academic Journal
Accession number :
edsdoj.4231a5d030ea4b69a94ca1146cfb2624
Document Type :
article
Full Text :
https://doi.org/10.1186/1471-2377-11-78