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MYPT1 reduction is a pathogenic factor of erectile dysfunction

Authors :
Wei Zhao
Jie Sun
Liang-Yu Yao
Dong Hang
Ye-Qiong Li
Cai-Ping Chen
Yu-Wei Zhou
Xin Chen
Tao Tao
Li-Sha Wei
Yan-Yan Zheng
Xie Ge
Chao-Jun Li
Zhong-Cheng Xin
Yang Pan
Xin-Zhu Wang
Wei-Qi He
Xue-Na Zhang
Bing Yao
Min-Sheng Zhu
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Reduced expression of myosin phosphatase target subunit 1 (MYPT1) is critical for the development of vasculogenic erectile dysfunction and a natural compound, lotusine, is found to increase MYPT1 expression and rescue penile smooth muscle function.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.42530947521a4ff28e376521282ac30a
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03716-y