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A comprehensive review of recent advances in chronic pancreatitis
- Source :
- Journal of Pancreatology, Vol 7, Iss 1, Pp 45-52 (2024)
- Publication Year :
- 2024
- Publisher :
- Wolters Kluwer Health/LWW, 2024.
-
Abstract
- Chronic pancreatitis (CP) is a multifaceted disorder influenced by environmental and genetic factors, with smoking and alcohol consumption being major contributors. Recent developments encompass the advent of innovative transgenic models and the identification of susceptibility genes, shedding light on the genetic aspect of CP. The pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction, inflammatory reactions, and fibrosis. Current research delves into understanding these molecular mechanisms. Pain, a pivotal symptom of CP, has been increasingly studied to develop effective therapeutic interventions. Diagnostic advancements, including endoscopic ultrasound, radiomics, and blood-based markers, have shown potential in enhancing early CP detection. Moreover, recent clinical trials have optimized treatment approaches, such as pancreatic stone fragmentation, stent placement, and decision-making between endoscopic and surgical procedures. Emerging therapies, including chemical pancreatectomy and gene therapy, present promising opportunities for improved CP management.
- Subjects :
- Diseases of the digestive system. Gastroenterology
RC799-869
Subjects
Details
- Language :
- English
- ISSN :
- 20965664 and 00000000
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Pancreatology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.42af6588b75d4192aa63d272df6a34fb
- Document Type :
- article
- Full Text :
- https://doi.org/10.1097/JP9.0000000000000161