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A comprehensive review of recent advances in chronic pancreatitis

Authors :
Sheng-Han Mao
Wen-Bin Zou
Xiao-Tong Mao
Zhao-Shen Li
Zhuan Liao
Source :
Journal of Pancreatology, Vol 7, Iss 1, Pp 45-52 (2024)
Publication Year :
2024
Publisher :
Wolters Kluwer Health/LWW, 2024.

Abstract

Chronic pancreatitis (CP) is a multifaceted disorder influenced by environmental and genetic factors, with smoking and alcohol consumption being major contributors. Recent developments encompass the advent of innovative transgenic models and the identification of susceptibility genes, shedding light on the genetic aspect of CP. The pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction, inflammatory reactions, and fibrosis. Current research delves into understanding these molecular mechanisms. Pain, a pivotal symptom of CP, has been increasingly studied to develop effective therapeutic interventions. Diagnostic advancements, including endoscopic ultrasound, radiomics, and blood-based markers, have shown potential in enhancing early CP detection. Moreover, recent clinical trials have optimized treatment approaches, such as pancreatic stone fragmentation, stent placement, and decision-making between endoscopic and surgical procedures. Emerging therapies, including chemical pancreatectomy and gene therapy, present promising opportunities for improved CP management.

Details

Language :
English
ISSN :
20965664 and 00000000
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Pancreatology
Publication Type :
Academic Journal
Accession number :
edsdoj.42af6588b75d4192aa63d272df6a34fb
Document Type :
article
Full Text :
https://doi.org/10.1097/JP9.0000000000000161