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Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

Authors :
Longqi Liu
Chuanyu Liu
Andrés Quintero
Liang Wu
Yue Yuan
Mingyue Wang
Mengnan Cheng
Lizhi Leng
Liqin Xu
Guoyi Dong
Rui Li
Yang Liu
Xiaoyu Wei
Jiangshan Xu
Xiaowei Chen
Haorong Lu
Dongsheng Chen
Quanlei Wang
Qing Zhou
Xinxin Lin
Guibo Li
Shiping Liu
Qi Wang
Hongru Wang
J. Lynn Fink
Zhengliang Gao
Xin Liu
Yong Hou
Shida Zhu
Huanming Yang
Yunming Ye
Ge Lin
Fang Chen
Carl Herrmann
Roland Eils
Zhouchun Shang
Xun Xu
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Heterogeneity in gene expression and epigenetic states exists across individual cells. Here, the authors develop scCAT-seq, a technique for simultaneously performing ATAC-seq and RNA-seq within the same single cell.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.42d28702523949a9a66ecb6233ecbdda
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-08205-7