microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma

Authors :: Silvia Ottaviani
Leandro Castellano
Source :: Molecular & Cellular Oncology, Vol 5, Iss 6 (2018)
Publication Year :: 2018
Publisher :: Taylor & Francis Group, 2018.
Abstract: We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.

Subjects :: tgf-β
micrornas
mir-100
mir-125b
let-7
emt
csc
stemness
metastasis
pdac
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282

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