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Computational Reconstruction of the Transcription Factor Regulatory Network Induced by Auxin in Arabidopsis thaliana L.

Authors :
Nadya A. Omelyanchuk
Viktoriya V. Lavrekha
Anton G. Bogomolov
Vladislav A. Dolgikh
Aleksandra D. Sidorenko
Elena V. Zemlyanskaya
Source :
Plants, Vol 13, Iss 14, p 1905 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

In plant hormone signaling, transcription factor regulatory networks (TFRNs), which link the master transcription factors to the biological processes under their control, remain insufficiently characterized despite their crucial function. Here, we identify a TFRN involved in the response to the key plant hormone auxin and define its impact on auxin-driven biological processes. To reconstruct the TFRN, we developed a three-step procedure, which is based on the integrated analysis of differentially expressed gene lists and a representative collection of transcription factor binding profiles. Its implementation is available as a part of the CisCross web server. With the new method, we distinguished two transcription factor subnetworks. The first operates before auxin treatment and is switched off upon hormone application, the second is switched on by the hormone. Moreover, we characterized the functioning of the auxin-regulated TFRN in control of chlorophyll and lignin biosynthesis, abscisic acid signaling, and ribosome biogenesis.

Details

Language :
English
ISSN :
22237747
Volume :
13
Issue :
14
Database :
Directory of Open Access Journals
Journal :
Plants
Publication Type :
Academic Journal
Accession number :
edsdoj.4387107d28af41faa0001faef077f8f5
Document Type :
article
Full Text :
https://doi.org/10.3390/plants13141905