Effect of Aluminium Chloride on Sexual Efficiency in Adult Male Rats

ABSTRACT The study was conducted to reveal the effect of oral administration of aluminium chloride on spermatogenesis and accessory sex organs in adult male rats. Aluminium chloride was administrated by oral intubation daily with two doses 40 and 80 mg/kg. body weight for periods 30 and 60 days for each. The results showed that aluminium chloride at both doses caused a significant reduction in sperm counts and the percentage of live sperm, with a significant increased in the percentage of morphologically abnormal sperm, and a significant reduction in averages of body weights, head epididymis, testis and prostate gland weights in rats treated with aluminium chloride at dose 80 mg/kg. body weight during the experimental period. While aluminium chloride at dose 40 mg/kg. body weight had no changes in the percentage of the morphologically abnormal sperm and in the body weight, testis and accessory reproductive organs weights. Synchronized with the physiological changes, histological alterations represented by vascular hyperemia, interstitial edema, multiplication of Leydig cells, coagulative necrosis, hyperplasia and sloughing of seminiferous tubular epithelium. The results concluded that administration of aluminium chloride to adult male rats would cause adverse effects on sexual efficiency.