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The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis

Authors :
Tylah Miles
Gerard F Hoyne
Darryl A Knight
Mark W Fear
Steven E Mutsaers
Cecilia M PrĂȘle
Source :
Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

Abstract Pulmonary fibrosis occurs in a heterogeneous group of lung disorders and is characterised by an excessive deposition of extracellular matrix proteins within the pulmonary interstitium, leading to impaired gas transfer and a loss of lung function. In the past 10 years, there has been a dramatic increase in our understanding of the immune system and how it contributes to fibrogenic processes within the lung. This review will compare some of the models used to investigate the pathogenesis and treatment of pulmonary fibrosis, in particular those used to study immune cell pathogenicity in idiopathic pulmonary fibrosis, highlighting their advantages and disadvantages in dissecting human disease.

Details

Language :
English
ISSN :
20500068
Volume :
9
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Clinical & Translational Immunology
Publication Type :
Academic Journal
Accession number :
edsdoj.4411332b0ed47deac6487b7ba36ef37
Document Type :
article
Full Text :
https://doi.org/10.1002/cti2.1153