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Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.44b4ac900f6945ee9370e7b87a8009d9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms13247