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Front-line chemo-immunotherapy for treating epithelial ovarian cancer: Part I CA125 and anti-CA125
- Source :
- Taiwanese Journal of Obstetrics & Gynecology, Vol 62, Iss 6, Pp 802-808 (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- The current standard therapy of epithelial ovarian cancer (EOC) is the combination of surgery (primary cytoreductive surgery or interval cytoreductive surgery) and platinum-based chemotherapy (mainly using paclitaxel and carboplatin either by neoadjuvant chemotherapy and/or by postoperative adjuvant chemotherapy) with/without adding targeted therapy (mainly using anti-angiogenesis agent- bevacizumab). After front-line chemotherapy, the advanced-stage EOC can be successfully controlled and three-quarters of patients can achieve a complete clinical remission. Unfortunately, nearly all patients will recur and progression-free survival (PFS) of these patients is seldom more than 3 years with a dismal median PFS of 12–18 months. With each recurrence, patients finally develop resistance to standard chemotherapy regimen, contributing to fewer than half of women who survive for more than 5 years after diagnosis with a median overall survival (OS) of 40.7 months. Due to the lower PFS and OS, particularly for those advanced-stage patients, novel therapeutic options during the front-line therapy are desperately needed to decrease the occurrence of recurrence, and the majority of them are still under investigation. It is well-known that overexpression of CA125 has been associated with attenuated cellular apoptosis, platinum chemotherapy resistance, tumor proliferation and disease progression, suggesting that anti-CA125 may play a role in the management of patients with EOC. The current review is a Part I which will focus on development of anti-CA125 monoclonal antibody, hoping that alternation of the front-line therapy by chemo-immunotherapy will be beneficial for prolonged survival of patients with EOC.
Details
- Language :
- English
- ISSN :
- 10284559
- Volume :
- 62
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Taiwanese Journal of Obstetrics & Gynecology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.44e4885599004834a33be20712119cee
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.tjog.2023.09.017