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mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

Authors :
Haomeng Wang
Zhao Chen
Zhenghua Wang
Jin Li
Zhihong Yan
Jinbo Yuan
Airu Zhu
Lan Chen
Ye Liu
Chenlong Hu
Ali Zhu
Guowei Li
Yuehu Li
Jie Deng
Liqiao Ma
Xiuwen Sui
Wei Miao
Junqiang Li
Xiuyu Zheng
Jinhua Piao
Yanfeng Yao
Juhong Rao
Chao Shan
Zhiming Yuan
Jincun Zhao
Tao Zhu
Source :
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1550-1553 (2022)
Publication Year :
2022
Publisher :
Taylor & Francis Group, 2022.

Abstract

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against different SARS-CoV-2 variants.

Details

Language :
English
ISSN :
22221751
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Emerging Microbes and Infections
Publication Type :
Academic Journal
Accession number :
edsdoj.45010f5b7974a4ea6d38515af71876f
Document Type :
article
Full Text :
https://doi.org/10.1080/22221751.2022.2081616