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Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties

Authors :
Vincenzo Giancotti
Natascha Bergamin
Palmina Cataldi
Claudio Rizzi
Source :
International Journal of Cell Biology, Vol 2018 (2018)
Publication Year :
2018
Publisher :
Hindawi Limited, 2018.

Abstract

High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. HMGA proteins were coordinated or associated with histone and DNA modification and the expression of the factors related to pluripotency. CSCs showed remarkable differences compared with ESCs and iPSCs.

Subjects

Subjects :
Cytology
QH573-671

Details

Language :
English
ISSN :
16878876 and 16878884
Volume :
2018
Database :
Directory of Open Access Journals
Journal :
International Journal of Cell Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.451d0306208c408ebe75e0f48b7dd15d
Document Type :
article
Full Text :
https://doi.org/10.1155/2018/3698078