Dysgerminoma of the Left Ovary in a Patient with Balanced Translocation 46X, t(X:1) (q22;q21): A Case Report

Koh Nagata, Takako Shimada, Chiaki Eishi, Masaki Nishi, Toru Murakami, Kazuaki Ohashi, Itsuki Kajimura, Kiyonori Miura Obstetrics and Gynecology, Nagasaki University Hospital, Nagasaki, JapanCorrespondence: Koh Nagata, Obstetrics and Gynecology, Nagasaki University Hospital, Nagasaki, Japan, Tel +81 95 819 7363, Fax +81 95 819 7365, Email k.nagata.nagasaki.obgyn@gmail.comAbstract: We report a case of dysgerminoma in a 22-year-old woman diagnosed with chromosomal abnormality, balanced translocation 46X,t(X:1)(q22;q21). She had received hormone replacement therapy for 7 years for primary amenorrhea. She visited a primary care physician because of lower abdominal distension, and a large tumor in the pelvis was discovered. She was admitted to our hospital for further examination of the pelvic tumor. She underwent laparotomy and was diagnosed with stage IIIA1 dysgerminoma (pT3apN0pM0) of the left ovary. Young female patients without the Y chromosome who are treated for primary amenorrhea may also develop malignant germ cell tumors; therefore, gynecologists should provide hormone replacement therapy and periodic pelvic evaluation.Keywords: primary amenorrhea, balanced translocation, dysgerminoma