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The association of chest computed tomography-defined visual emphysema and prognosis in patients with nonsmall cell lung cancer
- Source :
- ERJ Open Research, Vol 9, Iss 6 (2023)
- Publication Year :
- 2023
- Publisher :
- European Respiratory Society, 2023.
-
Abstract
- Background Although computed tomography (CT)-defined emphysema is considered a predictor of lung cancer risk, it is not fully clear whether CT-defined emphysema is associated with the prognosis of lung cancer. We aimed to assess the clinical impact of CT-defined emphysema on the survival of lung cancer. Methods In the prospective cohort study of nonsmall cell lung cancer (NSCLC), the correlation between CT-defined emphysema and clinical variables was analysed. A multivariable Cox regression model was built to assess the association between CT-defined emphysema and overall survival (OS) for up to 8.8 years. The differences in survival analyses were derived by Kaplan–Meier analysis and log-rank testing. Low attenuation area (LAA%) was defined as the per cent of voxels below −950 HU. Results 854 patients were included and CT-defined emphysema was present in 300 (35.1%) at diagnosis. Epidermal growth factor receptor (EGFR) wild-type (OR 1.998; p17% displayed poorer survival than those with LAA% ≤17% (median 432 versus 670 days; HR 1.564; p=0.020). Conclusions CT-defined emphysema, especially CLE with LAA%>17%, is an independent predictor of NSCLC prognosis. Moreover, prospective studies are needed to further explore this association.
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 23120541
- Volume :
- 9
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- ERJ Open Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.45e2da33df3b41aca1fd3d4d9277e340
- Document Type :
- article
- Full Text :
- https://doi.org/10.1183/23120541.00195-2023