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Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases

Authors :
W. K. Jacky Lam
Peiyong Jiang
K. C. Allen Chan
Wenlei Peng
Huimin Shang
Macy M. S. Heung
Suk Hang Cheng
Haiqiang Zhang
O. Y. Olivia Tse
Radha Raghupathy
Brigette B. Y. Ma
Edwin P. Hui
Anthony T. C. Chan
John K. S. Woo
Rossa W. K. Chiu
Y. M. Dennis Lo
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Epstein-Barr virus (EBV) is associated with different malignant diseases and circulating EBV DNA is a biomarker for nasopharyngeal carcinoma (NPC). Here, the authors report that plasma EBV DNA methylation profiles show disease-associated patterns and can help to distinguish NPC and non-NPC subjects.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4628833b96ef42e198ec3810d5f38f5d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11226-5