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Multifunctional Nanofibrous Hollow Microspheres for Enhanced Periodontal Bone Regeneration
- Source :
- Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
- Publication Year :
- 2024
- Publisher :
- Wiley, 2024.
-
Abstract
- Abstract Destructive periodontitis destroys alveolar bone and eventually leads to tooth loss. While guided bone regeneration, which is based on creating a physical barrier to hinder the infiltration of epithelial and connective tissues into defect sites, has been widely used for alveolar bone regeneration, its outcomes remain variable. In this work, a multifunctional nanofibrous hollow microsphere (NFHMS) is developed for enhanced alveolar bone regeneration. The NFHMS is first prepared via combining a double emulsification and a thermally induced phase separation process. Next, E7, a short peptide with high specific affinity to bone marrow‐derived stem cells (BMSCs), is conjugated onto the surface of NFHMS. After that, bone forming peptide (BFP), a short peptide derived from bone morphology protein 7 is loaded in calcium phosphate (CaP) nanoparticles, which are further encapsulated in the hollow space of the NFHMS‐E7 to form NFHMS‐E7‐CaP/BFP. The NFHMS‐E7‐CaP/BFP selectively promoted the adhesion of BMSCs and expelled the adhesion of fibroblasts and epithelial cells. In addition, the BFP is sustainedly released from the NFHMS‐E7‐CaP/BFP to enhance the osteogenesis of BMSCs. A rat challenging fenestration defect model showed that the NFHMS‐E7‐CaP/BFP significantly enhanced alveolar bone tissue regeneration. This work provides a novel bioengineering approach for guided bone regeneration.
- Subjects :
- alveolar bone regeneration
injectable
microspheres
nanofibers
periodontitis
Science
Subjects
Details
- Language :
- English
- ISSN :
- 21983844
- Volume :
- 11
- Issue :
- 28
- Database :
- Directory of Open Access Journals
- Journal :
- Advanced Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.465500609e8a44448b039f7426cbef4a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/advs.202402335