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Two cases of misleading Epstein-Barr virus infection and the role of EBV-DNA
- Source :
- IDCases, Vol 36, Iss , Pp e02001- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Two atypical cases of infectious mononucleosis in two teenagers with initially negative serology and non-evocative blood examinations are reported. The first patient had recently traveled to Africa, and Epstein-Barr virus negative serology led us to make many extensive investigations. The second patient complained of asthenia for a month, and PET/CT was performed to suspicion of lymphoma. PET scan revealed hypermetabolic lymph nodes in the supradiaphragmatic and subdiaphragmatic stations, along with18F-FDG uptake in the spleen and pharynx, raising more suspicion of lymphoma. Fortunately, Epstein-Barr virus DNA testing was performed and turned positive in both cases, and Epstein-Barr virus serology subsequently became positive. Diagnosing EBV infection can be challenging in rare cases, as EBV-specific serology may be negative in the early stages and confounding factors may be present. Therefore, Epstein-Barr virus DNA testing should be considered early in the diagnostic algorithm to prevent unnecessary investigations in similar cases.
Details
- Language :
- English
- ISSN :
- 22142509
- Volume :
- 36
- Issue :
- e02001-
- Database :
- Directory of Open Access Journals
- Journal :
- IDCases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.468f7be30f0d49899021fd1c625e826b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.idcr.2024.e02001