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Inhibitory Effect of Pycnogenol® on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis
- Source :
- Balkan Medical Journal, Vol 33, Iss 6, Pp 620-626 (2016)
- Publication Year :
- 2016
- Publisher :
- Galenos Publishing House, 2016.
-
Abstract
- Background: The supplement Pycnogenol® (PYC) has been used for the treatment of several chronic diseases including allergic rhinitis (AR). However, the in vivo effects on allergic inflammation have not been identified to date. Aims: To investigate the treatment results of PYC on allergic inflammation in a rat model of allergic rhinitis. Study Design: Animal experimentation. Methods: Allergic rhinitis was stimulated in 42 rats by intraperitoneal sensitization and intranasal challenge with Ovalbumin. The animals were divided into six subgroups: healthy controls, AR group, AR group treated with corticosteroid (dexamethasone 1 mg/kg; CS+AR), healthy rats group that were given only PYC of 10 mg/kg (PYC10), AR group treated with PYC of 3mg/kg (PYC3+AR), and AR group treated with PYC of 10 mg/kg (PYC10+AR). Interferon-γ (IFN-γ), interleukin-4 (IL-4), interleukin-10 (IL-10), and OVA-specific immunoglobulin E (Ig-E) levels of serum were measured. Histopathological changes in nasal mucosa and expression of tumor necrosis factor-α (TNF-α) and IL-1β were evaluated. Results: The levels of the IL-4 were significantly decreased in the PYC3+AR, PYC10+AR and CS+AR groups compared with the AR group (p=0.002, p
Details
- Language :
- English
- ISSN :
- 21463123 and 21463131
- Volume :
- 33
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Balkan Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.46c80448d9484e6884081189c554c198
- Document Type :
- article
- Full Text :
- https://doi.org/10.5152/balkanmedj.2016.150057