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Expression of Caveolin-1 in Rat Urinary Bladder with Cyclophosphamide-Induced Cystitis

Expression of Caveolin-1 in Rat Urinary Bladder with Cyclophosphamide-Induced Cystitis

Authors :
Sun-Ouck Kim
Seung Hee Song
Seung-Chul Lee
Kyung A Cho
Ho Song Yu
In Sang Hwang
Eu Chang Hwang
Dongdeuk Kwon
Source :
International Neurourology Journal, Vol 16, Iss 4, Pp 169-174 (2012)
Publication Year :
2012
Publisher :
Korean Continence Society, 2012.

Abstract

Purpose The purposes of this study were to investigate the effect of cyclophosphamide (CYP)-induced inflammatory cystitis on caveolin 1 in rat urinary bladder and to determine the role of these molecules in the bladder dysfunction that occurs in inflammatory change in rat urinary bladder. Methods Female Sprague-Dawley rats were divided into control (n=30) and experimental (n=30) groups. Cystitis in experimental group was induced by intraperitoneal injection of CYP (200 mg/kg). The control group underwent an intraperitoneal saline injection. After 3 days, urodynamic studies were done to measure the contraction interval and contraction pressure. The expression and cellular localization of caveolin 1 were determined by Western blot and immunofluorescent study in rat urinary bladder. Results In cystometrograms, the contraction interval (minute) was significantly increased in the CYP-induced cystitis rats (15.8±1.5) than in the control group (6.3±0.5) (P

Details

Language :
English
ISSN :
20934777 and 20936931
Volume :
16
Issue :
4
Database :
Directory of Open Access Journals
Journal :
International Neurourology Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.4730929456bf454a95b75281feb4910f
Document Type :
article
Full Text :
https://doi.org/10.5213/inj.2012.16.4.169