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Prognostic Value of Follicle-Stimulating Hormone Levels in Predicting Survival in Men With Idiopathic Pulmonary Arterial Hypertension

Authors :
Qian Wang
Yuan-Yuan Sun
Yu-Xia Huang
Lan Wang
Yu-Qing Miao
Ping Yuan
Source :
American Journal of Men's Health, Vol 16 (2022)
Publication Year :
2022
Publisher :
SAGE Publishing, 2022.

Abstract

The objective of the study was to assess the association between changes in plasma follicle-stimulating hormone (FSH) and the potential effect on idiopathic pulmonary arterial hypertension (IPAH) in male patients. A total of 116 male patients with IPAH and 53 healthy controls were included from XX Hospital. Plasma FSH concentration was assessed in all participants. Receiver operating characteristic curves were used to assess the mortality risk. Kaplan–Meier curve and Cox regression analyses were used to predict the value of FSH on the survival rate of male IPAH patients. The plasma FSH concentration in the IPAH group was significantly higher than that in the control group ( p = .017). Nonsurvivors had significantly higher levels of FSH than survivors ( p < .0001). FSH levels were positively correlated with World Health Organization Functional Class, mean pulmonary artery pressure, and pulmonary vascular resistance (PVR; p = .023, p < .0001, and p < .0001, respectively) and negatively correlated with 6-min walk distance (6MWD) and cardiac output (CO; p = .004 and p = .010). Cox regression model analysis showed that the levels of FSH were also the independent factors of mortality in male IPAH patients ( p < .0001). The IPAH patients with higher FSH levels had higher PVR, lower 6MWD, CO, and a lower survival rate ( p = .042, p = .003, p = .029, and p < .0001, respectively). Therefore, we identified that increased FSH levels were associated with disease severity in male patients with IPAH and independently predicted risk of disease and poor survival rate.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
15579891 and 15579883
Volume :
16
Database :
Directory of Open Access Journals
Journal :
American Journal of Men's Health
Publication Type :
Academic Journal
Accession number :
edsdoj.473ddbd98d8a4da2935fa0175cfd1b32
Document Type :
article
Full Text :
https://doi.org/10.1177/15579883211067084