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Cytotoxic Indole-Diterpenoids from the Marine-Derived Fungus Penicillium sp. KFD28

Authors :
Lu-Ting Dai
Li Yang
Fan-Dong Kong
Qing-Yun Ma
Qing-Yi Xie
Hao-Fu Dai
Zhi-Fang Yu
You-Xing Zhao
Source :
Marine Drugs, Vol 19, Iss 11, p 613 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Four new indole-diterpenoids, named penerpenes K-N (1–4), along with twelve known ones (5–16), were isolated from the fermentation broth produced by adding L-tryptophan to the culture medium of the marine-derived fungus Penicillium sp. KFD28. The structures of the new compounds were elucidated extensively by 1D and 2D NMR, HRESIMS data spectroscopic analyses and ECD calculations. Compound 4 represents the second example of paxilline-type indole diterpene bearing a 1,3-dioxepane ring. Three compounds (4, 9, and 15) were cytotoxic to cancer cell lines, of which compound 9 was the most active and showed cytotoxic activity against the human liver cancer cell line BeL-7402 with an IC50 value of 5.3 μM. Moreover, six compounds (5, 7, 10, 12, 14, and 15) showed antibacterial activities against Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633.

Details

Language :
English
ISSN :
16603397 and 47554916
Volume :
19
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.47538e47554916a928d6b2561d589c
Document Type :
article
Full Text :
https://doi.org/10.3390/md19110613