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Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression
- Source :
- Cardiovascular Therapeutics, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Isoliquiritigenin (ISL) is a flavonoid isolated mainly from the licorice plant, a traditional Chinese herb. ISL has shown anticancer, anti-inflammatory, antioxidant, and antidiabetic activities. However, the pharmaceutical effects of ISL on atherosclerosis are seldom explored. In this study, we used apolipoprotein E (ApoE) knockout mouse model and angiotensin II- (Ang II-) stimulated vascular smooth muscle cells (VSMCs) to elucidate the pharmacological mechanism of ISL to inhibit atherosclerosis. We found that in ApoE−/− mice ISL could attenuate atherosclerotic lesion, reduce serum lipid levels, and inhibit TRPC5 expression. In vitro, ISL inhibited Ang II-stimulated proliferation of VSMCs and suppressed Ang II-induced TRPC5 and PCNA expressions in a dose-dependent fashion. In conclusion, our findings provide novel insight into the pharmacological effects of ISL on atherosclerosis and suggest that ISL is beneficial for cardiovascular protection.
Details
- Language :
- English
- ISSN :
- 17555914 and 17555922
- Volume :
- 2020
- Database :
- Directory of Open Access Journals
- Journal :
- Cardiovascular Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.476c43e5d384c198a53e3db6c9264b3
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2020/1926249