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Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.47717c88ef24c69ad243e26e4c2ed5d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms13331