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Association of circulating proprotein convertase subtilisin/kexin type 9 levels and the risk of incident type 2 diabetes in subjects with prediabetes: a population-based cohort study

Authors :
Jie Shi
Weiwei Zhang
Yixin Niu
Ning Lin
Xiaoyong Li
Hongmei Zhang
Renming Hu
Guang Ning
Jiangao Fan
Li Qin
Qing Su
Zhen Yang
Source :
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-13 (2020)
Publication Year :
2020
Publisher :
BMC, 2020.

Abstract

Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by targeting the low-density lipoprotein receptor. Recent studies have shown that circulating PCSK9 is associated with glucose homeostasis and insulin resistance. The aim of this study was to examine the association of circulating PCSK9 levels and risk for the development of type 2 diabetes in individuals with prediabetes. Methods A population-based prospective study was conducted among 4205 Chinese subjects with prediabetes (average age 56.1 ± 7.5 years). Incident type 2 diabetes was diagnosed according to 2010 American Diabetes Association criteria. Circulating PCSK9 levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). The association of circulating PCSK9 levels with the risk of incident type 2 diabetes was assessed by Cox regression analysis. Results During a median follow-up period of 3.1 years, 568 subjects developed type 2 diabetes. Baseline circulating PCSK9 levels were significantly higher in female subjects developing incident type 2 diabetes than in those not developing incident type 2 diabetes (p

Details

Language :
English
ISSN :
14752840
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Cardiovascular Diabetology
Publication Type :
Academic Journal
Accession number :
edsdoj.47f2c413f78f4f1aa2677e8cafcd8348
Document Type :
article
Full Text :
https://doi.org/10.1186/s12933-020-01185-3