Back to Search Start Over

AAV-ie enables safe and efficient gene transfer to inner ear cells

Authors :
Fangzhi Tan
Cenfeng Chu
Jieyu Qi
Wenyan Li
Dan You
Ke Li
Xin Chen
Weidong Zhao
Cheng Cheng
Xiaoyi Liu
Yunbo Qiao
Bing Su
Shuijin He
Chao Zhong
Huawei Li
Renjie Chai
Guisheng Zhong
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

There are currently few AAV vectors that can effectively target the diverse cell types of the inner ear. Here the authors design AAV-ie for gene delivery to the mouse cochlea, targeting cochlear supporting cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4870f102e8cb420483631d047f236268
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11687-8