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DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

Authors :
Gemma Shireby
Emma L. Dempster
Stefania Policicchio
Rebecca G. Smith
Ehsan Pishva
Barry Chioza
Jonathan P. Davies
Joe Burrage
Katie Lunnon
Dorothea Seiler Vellame
Seth Love
Alan Thomas
Keeley Brookes
Kevin Morgan
Paul Francis
Eilis Hannon
Jonathan Mill
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Here the authors identify differences in cortical DNA methylation associated with Alzheimer’s disease pathology, and profiling nuclei from specific cell-types, find that most of these differences reflect variation occurring in non-neuronal cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.4898751694c340419ac1ca01ad423bfa
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-33394-7